Five Generalization about Enhancers

Most genes require enhancers for their transcription.

Enhancers are the major determinant of differential transcription in space and time.

Multiple signals for a enhancer at a distance from the promoter. Several enhancers for a given gene. Several factors for each enhancer.

The interaction between the proteins bound to the enhancer sites with the transcription apparatus assembled at the promoter is thought to regulate transcription.

Enhancers are modular. There are DNA elements that confer temporal and spatial gene expression, and these can be mixed and matched. The DNA element are shared.