Physiological role and regulation mechanism of mitophagy

Measuring in vivo mitophagy in mt-Keima mice

• Elucidation of physiological and pathological role of mitophagy by using mt-Keima model organisms

• Identification of central regulators and upstream signal pathway for mitophagy

• Exploring the effect of improved mitophagy for human diseases

Mitochondria function in Senescence and cancer

• Study of the changes in mitochondria function during tumorigenesis and cellular senescence

• Identification of mitochondria hub molecules and its role in tumorigenesis and senescence

Regulation mechanism of cellular senescence and aging

• Identification of novel regulators for cellular senescence

• Elucidation of molecular mechanism for premature senescence upon genotoxic stresses