Peroxiredoxin 3 deficiency induces cardiac hypertrophy and dysfunction by impaired mitochondrial quality control.(2022) Seong Keun Sonn, Eun Ju Song, Seungwoon Seo, Young Yeon Kim, Jee-Hyun Um, Franklin Joonyeop Yeo, Da Seul Lee, Sejin Jeon, Mi-Ni Lee, Jing Jin, Hyae Yon Kweon, Tae Kyeong Kim, Sinai Kim, Shin Hye Moon, Sue Goo Rhee, Jongkyeong Chung, Jaemoon Yang, Jin Han, Eui-Young Choi, Sung Bae Lee, Jeanho Yun, Goo Taeg Oh. Redox Biol. 2022 May; 51:102275. doi: 10.1016/j.redox.2022.102275.

p53 regulates mitochondrial dynamics by  inhibiting Drp1 translocation into mitochondria during cellular senescence. (2020) Kim YY, Um JH, Yoon JH, Lee DY, Lee YJ, Kim DH, Park JI, Yun J. FASEB J. 2020 Feb;34(2):2451-2464. doi: 10.1096/fj.201901747RR. Epub 2019 Dec 13.FASEB J. 2020. PMID: 31908078
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The effect of coniferaldehyde on neurite outgrowth in neuroblastoma Neuro2a cells.(2019) Jeon J, Kwon H, Cho E, Kim KS, Yun J, Lee YC, Kim DH. Neurochem Int. 2019 Dec;131:104579. doi: 10.1016/j.neuint.2019.104579. Epub 2019 Oct 12. PMID:31614166

Assessment of mitophagy in mt-Keima Drosophila revealed an essential role of the PINK1-Parkin pathway in mitophagy induction in vivo.(2019) Kim YY, Um JH, Yoon JH, Kim H, Lee DY, Lee YJ, Jee HJ, Kim YM, Jang JS, Jang YG, Chung J, Park HT, Finkel T, Koh H, Yun J. FASEB J. 2019 Sep;33(9):9742-9751. doi: 10.1096/fj.201900073R. PMID:31120803
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Drp1 Phosphorylation Is Indispensable for Steroidogenesis in Leydig Cells. (2019) Park JE, Kim YJ, Lee SG, Kim JY, Chung JY, Jeong SY, Koh H, Yun J, Park HT, Yoo YH, Kim JM. Endocrinology. 2019 Apr 1;160(4):729-743. doi: 10.1210/en.2019-00029. PMID:30689811

Sensitive Measurement of Mitophagy by Flow Cytometry Using the pH-dependent Fluorescent Reporter mt-Keima. Um JH, Kim YY, Finkel T, Yun J. (2018) J Vis Exp. 2018 Aug 12;(138). doi: 10.3791/58099. [Abstract][PDF file]

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence. Kim YY, Um JH, Yun J. (2018) J Vis Exp. 2018 Aug 12;(138). doi: 10.3791/57890.[Abstract][PDF file]

Downregulation of Drp1, a fission regulator, is associated with human lung and colon cancers. Kim YY, Yun SH, Yun J. (2018)  Acta Bioch Bioph Sin . 2018 Feb 1;50(2):209-215. doi: 10.1093/abbs/gmx137. [Abstract][PDF file]

Cooperation between p21 and Akt is required for p53-dependent cellular senescence. Kim YY, Jee HJ, Um JH, Kim YM, Bae SS, Yun J. (2017) Aging Cell. 2017 Oct;16(5):1094-1103. doi: 10.1111/acel.12639. [Abstract][PDF file]

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Checkpoint-dependent phosphorylation of Med1/TRAP220 in response to DNA damage. Kim HJ, Yun J. (2017) Acta Bioch Bioph Sin. Apr 19:1-7. doi: 10.1093/abbs/gmx036. [Epub ahead of print] PMID:28430840

Emerging role of mitophagy in human diseases and physiology. Um JH, Yun J. (2017) BMB Rep. 2017 Apr 3. pii: 3810. [Epub ahead of print] PMID:28366191

HO-1 inhibits preadipocyte proliferation and differentiation at the onset of obesity via ROS dependent activation of Akt2. Wagner G, Lindroos-Christensen J, Einwallner E, Husa J, Zapf TC, Lipp K, Rauscher S, Gröger M, Spittler A, Loewe R, Gruber F, Duvigneau JC, Mohr T, Sutterlüty-Fall H, Klinglmüller F, Prager G, Huppertz B, Yun J, Wagner O, Esterbauer H, Bilban M. (2017)  Sci Rep. 2017 Jan 19;7:40881. doi: 10.1038/srep40881. PMID:28102348

Akt3 knockdown induces mitochondrial dysfunction in human cancer cells. Kim M, Kim YY, Jee HJ, Bae SS, Jeong NY, Um JH, Yun J. (2016) Acta Biochim Biophys Sin. 2016 May;48(5):447-53. [Abstract]

Measuring In Vivo Mitophagy. Sun N*, Yun J*, Liu J, Malide D, Liu C, Rovira I, Holmstrom KM, Fergusson MM, Yoo HY, Combs CA, Finkel T. (2015) Mol Cell. Nov 19; 60(4):685-696 (*co-first authors) [Abstract][PDF file]

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Targeted inhibition of mitochondrial Hsp90 induces mitochondrial elongation in Hep3B hepatocellular carcinoma cells undergoing apoptosis by increasing the ROS level. Yoo SH, Kim HY, Rho JH, Jeong SY, Yun J, Yun I, Park HT, Yoo YH.(2015) Int J Oncol. 47(5):1783-92. [Abstract][PDF file]

Clinical significance of Peroxisome Proliferator-Activated Receptor γ and TRAP220 in Patients with Operable Colorectal Cancer. Kwon KA*, Yun J*, Oh SY, Seo BG, Lee S, Lee JH, Kim SH, Choi HJ, Roh MS, Kim HJ. Cancer Res Treat. (2015) 48(1):198-207. [Abstract] (*Co-first author)

Mitohormesis. Yun J, Finkel T.(2014) Cell Metab. 19(5):757-66 Review.[Abstract][PDF file]

The emerging links between sirtuins and autophagy. Lee IH, Yun J, Finkel T.  (2013) Methods Mol Biol. 1077:259-71.

p53 interferes with microtubule-stabilizing agent-induced apoptosis in prostate and colorectal cancer cells. Kim JY, Chung JY, Lee SG, Kim YJ, Park JE, Yun J, Park YC, Kim BG, Yoo YH, Kim JM. Int J Mol Med. 2013 Jun;31(6):1388-1394.

Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins, SMAC, HtrA2 and ARTS. Kim JB, Kim SY, Kim B, Lee H, Kim I, Yun J, Jo Y, Oh T, Jo Y, Chae HD, Shin DY. (2013)  J Biol Chem. Apr 26;288(17):12014-21.

The inhibition of Nek6 function sensitizes human cancer cells to premature senescence upon serum reduction or anticancer drug treatment. Jee HJ, Kim HJ, Kim AJ, Song N, Kim M, Lee HJ, Yun J. (2013) Cancer Lett. 2013 Jul 10;335(1):175-82.[Abstract][PDF file]

p21WAF1/CIP1 deficiency induces mitochondrial dysfunction in HCT116 colon cancer cells. Kim AJ, Jee HJ, Song N, Kim M, Jeong SY, Yun J. (2013)Biochem Biophys Res Commun, Jan 11, 430(2):653-8.[Abstract][PDF file]

Melatonin suppresses doxorubicin-induced premature senescence of A549 lung cancer cells by ameliorating mitochondrial dysfunction. Song N, Kim AJ, Kim HJ, Jee HJ, Kim M, Yoo YH, Yun J. (2012) J Pineal Res. Nov;53(4):335-43.[Abstract][PDF file]

Loss of Med1/TRAP220 promotes the invasion and metastasis of human non-small-cell lung cancer cells by modulating the expression of metastasis-related genes. Kim HJ, Roh MS, Son CH, Kim AJ, Jee HJ, Song N, Kim M, Seo SY, Yoo YH, Yun J. (2012) Cancer Lett. Aug 28;321(2):195-202.[Abstract][PDF file]

DNA damage induces downregulation of PEPCK and G6P gene expression through degradation of PGC-1α. Kim HJ, Jee HJ, Yun J. (2011) Acta Bioch Bioph Sin. August;43(8):589-594.[Abstract][PDF file]

Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis. Kim EK, Yun SJ, Ha JM, Kim YW, Jin IH, Yun J, Shin HK, Song SH, Kim JH, Lee JS, Kim CD, Bae SS. (2011) Oncogene. Jun 30;30(26):2954-63

Nek6 suppresses the premature senescence of human cancer cells induced by camptothecin and doxorubicin treatment. Jee HJ, Kim HJ, Kim AJ, Song N, Kim M, Yun J. (2011)Biochem Biophys Res Commun. 408(4):669-73. [Abstract][PDF file]

Glucose deprivation is associated with Chk1 degradation through the ubiquitin-proteosome pathway and effective checkpoint response to replication blocks. Kim AJ, Kim HJ, Jee HJ, Song N, Kim M, Bae YS, Chung JH, Yun J. (2011) Biochim Biophys Acta-Mol Cell Res. 1813(6)1230-8 [Abstract] [PDF file]

A different TRAP220 expression in distinct histologic subtypes of lung adenocarcinoma and the prognostic significance. Yun J, Son CH, Um SJ, Kwon HC, Choi PJ, Roh MS. (2011)Lung Cancer. 71(3):312-8[Abstract] [PDF file]

Nek6 overexpression antagonizes p53-induced senescence in human cancer cells. Jee HJ, Kim AJ, Song N, Kim HJ, Kim M, Koh H, Yun J. (2010) Cell Cycle, 9(23); 4703-4710 [Abstract][PDF file]

Fenofibrate antagonizes Chk2 activation by inducing Wip1 expression: Implications for cell proliferation and tumorigenesis. Joe Y, Do MH, Seo E, Kang S, Park HT, Yun J, Lee HJ. (2010)Life Sci. 2010 May 8;86(19-20):716-721

A pertussis toxin sensitive G-protein-independent pathway is involved in serum amyloid A-induced formyl peptide receptor 2-mediated CCL2 production. Lee HY, Kim SD, Shim JW, Kim HJ, Yun J, Baek SH, Kim K, Bae YS. (2010) Exp Mol Med. Apr 30;42(4)302-309.

Functional expression of formyl peptide receptor family in human NK cells. Kim SD, Kim JM, Jo SH, Lee HY, Lee SY, Shim JW, Seo SK, Yun J, Bae YS. (2009)J Immunol. Nov 1;183(9):5511-7.

UV light induces premature senescence in Akt1-null mouse embryonic fibroblasts by increasing intracellular levels of ROS. Jee HJ, Kim HJ, Kim AJ, Bae YS, Bae SS, Yun J. (2009) Biochem Biophys Res Commun.  383(3):358-62. [Abstract][PDF file]

Lysophosphatidylglycerol inhibits formyl peptide receptorlike-1-stimulated chemotactic migration and IL-1beta production from human phagocytes. Shim JW, Jo SH, Kim SD, Lee HY, Yun J, Bae YS. (2009) Exp Mol Med. Aug 31;41(8):584-91.

Akt2, but not Akt1, is required for cell survival by inhibiting activation of JNK and p38 after UV irradiation. Kim MA, Kim HJ, Jee HJ, Kim AJ, Bae YS, Bae SS, Yun J. (2009)  Oncogene, 28(9) 3379-84 [Abstract] [PDF file]

LL-37 inhibits serum amyloid A-induced IL-8 production in human neutrophils. Lee HY, Kim SD, Shim JW, Lee SY, Yun J, Bae YS. (2009)Exp Mol Med. May 31: 41(5):325-33.

Activation of formyl peptide receptor like-1 by serum amyloid A induces CCL2 production in human umbilical vein endothelial cells. Lee HY, Kim SD, Shim JW, Yun J, Kim K, Bae YS. (2009) Biochem Biophys Res Commun. Mar 6;380(2):313-7.

Differential regulation of Akt/protein kinase B isoforms during cell cycle progression. Yun SJ, Tucker DF, Kim EK, Kim MS, Do KH, Ha JM, Lee SY, Yun J, Kim CD, Birnbaum MJ, Bae SS. (2009) FEBS Lett. 2009 Feb 18. 583(4) 685-690

Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation. Lee MY, Kim HJ, Kim MA, Jee HJ, Kim AJ, Bae YS, Park JI, Chung JH, Yun J. (2008) Cell Cycle, 7(17) 2705-2709. [Abstract][PDF file]

Collagen-binding motif peptide, a cleavage product of osteopontin, stimulates human neutrophil chemotaxis via pertussis toxin-sensitive G protein-mediated signaling. Kim MK, Kim SD, Lee HY, Lee SY, Shim JW, Yun J, Kim JM, Min DS, Yoo YH, Bae YS. (2008) FEBS Lett. Oct 15, 582(23), 3379-84

Serum amyloid A induces CCL2 production via formyl peptide receptor-like 1-mediated signaling in human monocytes. Lee HY, Kim SD, Shim JW, Lee SY, Lee H, Cho KH, Yun J, Bae YS. (2008) J Immunol. Sep 15, 181(6), 4332-4339.

Lysophosphatidylglycerol stimulates chemotactic migration in human natural killer cells. Lee SY, Lee HY, Kim SD, Jo SH, Shim JW, Lee HJ, Yun J, Bae YS. (2008) Biochem Biophys Res Commun Sep12; 374(1), 147-151.

Lysophosphatidylserine stimulates chemotactic migration in U87 human glioma cells. Jo SH, Kim SD, Kim JM, Lee HY, Lee SY, Shim JW, Yun J, Im DS, Bae YS. (2008) Biochem Biophys Res Commun. Jul 18; 372(1), 147-151

Lysophosphatidylethanolamine stimulates chemotactic migration and cellular invasion in SK-OV3 human ovarian cancer cells: Involvement of pertussis toxin-sensitive G-protein coupled receptor. Park KS, Lee HY, Lee SY, Kim MK, Kim SD, Kim JM, Yun J, Im DS, Bae YS. (2007) FEBS Lett.  Sep 18;581(23):4411-6.

Alkylating agent methyl methanesulfonate (MMS) induces a wave of global protein hyperacetylation: Implications in cancer cell death. Lee MY, Kim MA, Kim HJ, Bae YS, Park JI, Kwak JY, Chung JH, Yun J. (2007) Biochem Biophys Res Commun. 360(2);483-9 [Abstract] [PDF file]

Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif. Kim MA, Kim HJ, Brown AL, Lee MY, Bae YS, Park JI, Kwak JY, Chung JH, Yun J. (2007). Exp Mol Med. 39(2):205-12. [Abstract] [PDF file]

Phytosphingosine-1-phosphate stimulates chemotactic migration of L2071 mouse fibroblasts via pertussis toxin-sensitive G-proteins. Kim MK,  Park KS, Lee H, Kim YD, Yun J, Bae YS. (2007) Exp Mol Med. Apr 30;39(2):185-94.

Serum amyloid A induces WISH cell apoptosis. Jo SH, Yun J, Kim JM, Lee C, Baek SH, Bae YS. (2007) Acta Pharmacol Sin. Jan;28(1):73-80.

Sphingosine-1-phosphate stimulates rat primary chondrocyte proliferation. Kim MK, Lee HY, Kwak JY, Park JI, Yun J, Bae YS. (2006) Biochem Biophys Res Commun. Jun 23, 345(1);67-73

Pioglitazone, a synthetic ligand for PPARgamma, induces apoptosis in RB-deficient human colorectal cancer cells. Lee CJ, Han JS, Seo CY, Park TH, Kwon HC, Jeong JS, Kim IH, Yun J, Bae YS, Kwak JY, Park JI. (2006) Apoptosis, Mar 2, 11(3), 401-411.

Impaired Spindle Checkpoint Response of Brca1-deficient Mouse Embryonic Fibroblasts (MEFs) to Nocodazole Treatment. Kim MA, Kim H, Yun J. (2006)J. Life. Sci. 16(1) 12-16 [PDF file]

Lysophosphatidic acid stimulates cell proliferation in rat chondrocytes. Kim MK, Lee HY, Park KS, Shin EH, Jo SH, Yun J, Lee SW, Yoo YH, Lee YS, Baek SH, Bae YS. Biochem Pharmacol. 2005 Dec 5. 70(12) 1764-1771. 

Transcription repression of a CCAAT-binding transcription factor CBF/HSP70 by p53. Chae, H.D., Yun, J., Shin, D.Y. (2005) Exp Mol Med. 37(5),488-91. [Abstract] [PDF file]

Hypersensitivity of Brca1-deficient MEF to DNA interstrand cross-linking agent mitomycin C is associated with defect in homologous recombination repair and aberrant S-phase arrest. Yun, J., Zhong, Q., Kwak, J.Y., Lee, W. H. (2005)Oncogene. June 9; 24(25) 4009-40016.  [Abstract] [PDF file]

Involvement of Brca1 in DNA interstrand cross-link repair through homologous recombination-independent process. Yun, J. (2005)August 30. J. Life. Sci. 15(4) 542-547.

Serum amyloid A stimulates matrix-metalloproteinase-9 activity via formyl peptide receptor like-1-mediated signaling in human monocytic cells. Lee, H.Y., Kim, M.K., Park, K.S., Bae, Y.H., Yun, J., Park, J.I., Kwak, J.Y., Bae, Y.S. (2005) Biochem Biophys Res Commun. 330(3) 989-998.

Cdk2-dependent phosphorylation of the NF-Y transcription factor is essential for expression of the cell cycle-regulatory genes and cell cycle G1/S and G2/M transitions. Chae, H.D., Yun, J., Bang Y.J., Shin, D.Y. (2004) Oncogene. 23(23):4084-8 [Abstract] [PDF file]

Identification of a novel non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells. Utomo, A., Jian, X., Furuta, S., Yun, J., Levin, D.S., Wang, Y.C., Desai, K. V., Green, J. E., Chen, P. L., Lee, W. H. (2004) J Biol Chem. Oct 15 279(42):43522-9.

Degradation of the transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45 upon DNA damage. Yun, J. and Lee, W. H. (2003) Mol. Cell. Biol. 23: 7305-14. [Abstract] [PDF file]

Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway. Yun, J., Chae, H.D., Choi, T.S., Kim, E.H., Bang, Y.J., Chung, J., Choi, K.S., Mantovani, R., Shin, D.Y. (2003) J. Biol Chem. 278: 36966-72 [Abstract] [PDF file]

p53 and its homologues, p63 and p73, induce replicative senescence through inactivation of NF-Y transcription factor. Jung, M.*, Yun, J.*, Chae, H.D., Kim, S.C., Choi, T.S. and Shin, D.Y. (2001) Oncogene. 20:5818-25 (*Co-first author) [Abstract] [PDF file]

Constitutive activation of cyclin B1-associated cdc2 kinase overrides p53-mediated G2-M arrest. Park, M., Chae, H.D., Yun, J., Jung, M., Kim, Y.S., Kim, S.H., Han, M.H. and Shin, D.Y. (2000) Cancer Res. 60: 542-5. [Abstract] [PDF file]

p53 Negatively regulated cdc2 transcription via the CCAAT-binding NF-Y transcription factor. Yun, J., Chae, H. D., Choi, H. E., Chung, J., Yoo, H. S., Han, M. H., Shin, D. Y. (1999) J. Biol. Chem., 274: 29677-82. [Abstract] [PDF file]

Isolation of a new member of DnaJ-like heat shock protein 40(Hsp40) form human liver. Hoe, K. L., Won, M., Chung, K. S., Jang, Y. J., Lee, S. B., Kim, D. U., Lee, J. W., Yun, J., Yoo, H. S. (1998) Biochem. Biophys. Acta. 1383:1 4-8

A novel strategy for isolating suppresor mutants from sporulation-deficient yeast mutants. Shin, D.Y., Yun, J. and H.S., Yoo. (1997) J. Microbiol. 35: 61-65.